Titul

Last updated: 01.10.2005.

Pavel Vassilev Stavrev

Adress:

Home: 11135-83Ave, Apt 2109

            Edmonton, AB, T6G 2C6

            Canada

Work: Department of Medical Physics

            Cross Cancer Institute

            11560 University Avenue

            Edmonton, Alberta, T6G 1Z2, Canada

Telephone:

home (+1 780 989 3368)

work (+ 1 780 989 4334)

E-mail: pstavrev@phys.ualberta.ca

Homepage: http://med.phys.ualberta.ca/pstavrev/

Date of Birth: September 4, 1957

Place of Birth: Varna, Bulgaria

Citizenships: Bulgaria, New Zealand

Education History:

· 93 - 97 - D.Phil., Department of Physics, Waikato University, Hamilton, New Zealand

· 81 - 82 - M Sc., Faculty of Physics, Sofia University, Sofia, Bulgaria

· 77 - 81 - B.Sc., Faculty of Physics, Sofia University, Sofia, Bulgaria

· 1975 - Grammar School, Varna, Bulgaria

Employment History:

9/2001 – Currently Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada, Associate Medical Physicist

· Deriving formulae for the slope of the dose-response curve based on different radiobiological models

· Investigating the Effect of Cell Repopulation on the Tumor Response to Fractionated External Radiotherapy

· On some limitations of the application of the NTCP model describing the response of organs with ‘relatively serial’ structure

· Fractionation correction to Lyman’s model

· Evaluation of a closed-form tumor control probability solution

· A TCP - NTCP estimation module based on known models, parameter sets and dose-volume histograms.

12/2000 – 9/2001 Medical Physics Unit, Montreal General Hospital & McGill University, Montreal, Research Associate

· Prostate IMRT fractionation strategies: two-phase treatment versus simultaneous integrated boost

· IMRT inverse treatment planing optimization based on physical constraints and biological objectives

12/1997 – 12/2000 Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Postdoctoral Research Fellow

· Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics

· Modeling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits

· Analysis of data using normal tissue complication probability models; fine-tuning of existing models and development of new ones

· Binomial confidence limits to clinical data and animal experiments - a Bayesian approach

1991-1993 Stelana-90 (Computer firm), Owner

· Computer services and sales

· Development of an information system for observation of the first contour liquid chemical composition in a water- water nuclear reactor. Evaluating and controlling high temperature pH values.

· Development of an expert system for individualization and optimization of drug therapy.

1990-1991 Institute of Nuclear Research and Nuclear Energy, Bulgarian Academy of Science, Sofia, Research Fellow

· Mass composition of Cosmic Rays

· Electromagnetic cascading of ultra - high energy photons

1987-1990 Institute of Solid State Physics, Bulgarian Academy of Science, Sofia, Research Fellow

· Development of an algorithm and software estimating the parameters of Si-SiO plates on the basis of CV curves measurement.

· Monte Carlo simulations of the electron propagation in an inverse layer.

· Creating a program for numerical optimization of spherical lenses with quadratic gradient index.

1985-1987 Cosmic Ray Laboratory, Physical Institute P.N.

Lebedev, Soviet Academy of Science, Moscow, USSR (former), Research Fellow

· I have participated in the creation of the cosmic ray experiment "HADRON" on the Tien-Shan Cosmic Ray Station. My work was related to the development of a new nanosecond accuracy device for time difference measurements in extensive air shower registration.

· Searching for unstable particles (charmed baryons) in the cascades initiated by single hadrons

1982-1985 Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Science, Sofia, Physicist

· Working on a cosmic ray experiment on peak Mussala, Bulgaria, measuring the secondary cosmic ray particles. Servicing the muon telescope and participating in the creation of the Neutron Supermonitor.

· I worked also over the development of a program, solving two-dimensional plus time parabolic partial differential equation (for the purposes of modeling Cosmic Rays modulation in the Heliosphere).

Teaching Experience:

2002 – 4 lectures - Radiobiology course, CCI & University of Alberta

2001 – 4 lectures - Radiobiology course, CCI & University of Alberta

1997 - 6 lectures - first year Astronomy course, Waikato University, Hamilton, NZ

1995 - Astrophysics Course (Solar Physics, Cosmic Rays and Compact Objects), Waikato University, Hamilton, NZ

Publications: 27 papers in refereed journals & 41 conference presentations

Research Interests: My research interests, as can be seen from the papers in which I am coauthor, are diverse and include Medical Physics, Astrophysics and Biophysics. Other topics of interest – Philosophy (Lao Tzu, Bhagavad Gita, Plato, Diogenis, Kant, Logical Positivists), History, Mathematics.

LIST OF PUBLICATIONS

29. Inverse treatment planning by physically constrained minimization of a biological objective function. Stavrev P, Hristov D, Warkentin B, Sham E, Stavreva N and Fallone BG submitted to Medical Physics

28. Investigating the Effect of Cell Repopulation on the Tumor Response to Fractionated External Radiotherapy N. A. Stavreva, P. V. Stavrev, B. Warkentin, and B.G. Fallone submitted to Medical Physics

27. Breast radiotherapy with inclusion of the internal mammary nodes: A comparison of techniques with 3 dimensional planning. D. Severin, S. Connors, H. Thompson, S. Rathee, P. Stavrev, J. Hanson, IJROBP, 2003 (in press)

26. Some limitations of the application of the NTCP model describing the response of organs with 'relatively serial' structure. N. A. Stavreva and P. V. Stavrev, Int J Radiat Biol, vol. 78, pp. 948-50; author reply 951-2, 2002.

25. Derivation of the expressions for gamma50 and D50 for different individual TCP and NTCP models. N. Stavreva, P. Stavrev, B. Warkentin, and B. G. Fallone, Phys Med Biol, vol. 47, pp. 3591-604, 2002.

24. On the implementation of dose-volume objectives in gradient algorithms for inverse treatment planning. Hristov, D., Stavrev, P., Sham, E., and Fallone, B. G. (2002). Med Phys, 29(5), 848-56.

23. On the consistent use of organ definitions and radiobiological models for the evaluation of complication probabilities of "tubular" organs. Stavrev PV, Hristov DH and. Seuntjens JP, IJROBP,2002

22. The Application of Biological Models to Clinical Data. P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. Physica Medica, 17, 2, p2, 2001

21. Modeling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits. N. Stavreva, A. Niemierko, P. Stavrev, M Goitein. International Journal of Radiation Biology, 77, 5, 2001

20. Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics. P Stavrev, N Stavreva, A Niemierko and M Goitein. Phys. Med. Biol. 46, 5, p1501-18, 2001

19. Fraction size and dose parameters related to the incidence of pericardial effusions: Regarding Martel et al. Letter to the Editor. IJROBP 40(1): 55-161; 1998. Stavrev P, Stavrev N. Int. J. of Rad. Onc. Biol. Phys. 48: (2) 611-613 Sep 1 2000

18. A Study of Objective Functions for Organs with Parallel and Serial Architecture PV Stavrev, NA Stavreva, WH Round. Australasian Physical and Engineering Sciences in Medicine, 20, 1, 1997

17. A Mathematical Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours. Stavreva N. Stavrev P., Round WH. Acta Oncologica 35, 6, 1996, p727

16. A New Method for Optimum Dose Distribution Determination Taking Tumour Mobility into Account. PV Stavrev, NA Stavreva, WH Round. Physics in Medicine and Biology, 41, (1996), p1679-1689

15. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours. NA Stavreva, PV Stavrev, WH Round. Astralasian Physical and Engineering Sciences in Medicine, vol. 19, No 1, 1996, p9

14. Comment on 'A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density' by Webb and Nahum, Letter to the Editor. Stavreva N. Stavrev P., Round WH. Physics in Medicine and Biology, 40, (1995), p1731-1738

13. New Algorithm for Analysis of Data Obtained by Means of Circular Dichroism Titration Method. N.Stavreva, V.Ruseva, D.Michailova, P.Stavrev. Arzneimittel Forschung (Drug Research), 43(I), 73, 1993

12. Mass composition of Cosmic Rays with E ~ 10¹⁴ - 10¹⁶eV. New treatment of Tien-Shan and Akeno data. Stavrev P., Gavritova-Stavreva N. , Petrov S. J. Phys. G:Nucl. Phys. (1992), p1832

11. Electromagnetic Cascading of Ultra - High Energy Photons ( E>5x10¹⁷ eV ) in the Earth's Magnetic Field. H. P. Vankov and P. V. Stavrev. Physics Letters B, v. 266, 1991

10. Nonlinear Theory of Relaxation of Unstable Magnetization Precession in ³He-A. IA Fomin, DV Shopova, PV Stavrev. Journ. Exp. &Theor. Phys., v. 99, 1991, 1

9. Array for cascade’s form investigation with energies 10¹³-10¹⁵ eV using the cherenkov radiation in the atmosphere. S. Abdrashitov, Yu. Vasilyuk, N. Gavritova-Stavreva, V. Zhukov, S. Zujkov, A. Morozov, S. Nikolsky,A. Smirnov, P. Stavrev, V. Yakovlev. Preprint 189 P. N. Lebedev FIAN Moscow 1989

8. Analysis of the Dependence of the Time and Amplitude Characteristics of a Scintillation Detector on its Box Geometry (in Russian). P. Stavrev, N. Stavreva, Ch. Vankov, K. Barkalov, V. Yakovlev. Bulg. J. Phys. 16 (1989), 2,p 150

7. Analysis of Extensive Air Showers Zenith and Azimuth Distributions with E > 0.3 PeV Observed on the Tien-Shan Cosmic Ray Array (in Russian). K.Barkalov, P.Stavrev, N.Nesterova, I.Kirov. Preprint 19 P. N. Lebedev, FIAN 1988

6. About Cross-Section Increase of Hadron Interaction with Atmospheric Atomic Nuclei Based on the Altitude Dependence of EAS with E > 10 PeV (in Russian). K.Barkalov, A.Dubovy, P.Dyatlov, N.Nesterova, P.Stavrev. Kratkie soobstenia po fizike ,1987,12,p 25

5. Errors' Estimation of EAS Axis Angular Coordinates Determination ( in Russian ). J. Stamenov, P. Stavrev. Voprosy Atomnoi Nauki i Tehniki(VANT), (1987)

4. Cherenkov Detector for Atmospheric High-Energy Cascades Investigation (in Russian). N. Aliev, T. Alimov, M. Kakharov, B. Machmudov, H. Nasrullaev, N. Sirodyev, N. Hakimov, Yu. Vasiluk, N. Gavritova-Stavreva, V. Zhukov, A. Morozov, S. Nikolsky, A. Smirnov, P. Stavrev, V. Yakovlev . Izvestiy AN SSSR, ser. fiz., t. 50 N 11 (1986)

3. "Hadron" Array for Investigation of Primary Cosmic Rays and Characteristics of Nuclear Interactions in the Atmosphere (in Russian). S. Abdrashitov, D. Adamov, V. Arabkin, V. Asejkin, B. Afanasiev, K. Barkalov, R. Bejsenbaev, Yu. Vasiluk, N. Vildanov, L. Vildanova, N. Gavritova-Stavreva, A. Guliaew, A. Dubovy, P. Diatlov V. Zhukov,B. Kadyrsizov, A. Kvashnin, A. Kolchin, A. Kruglov, A. Morozov, R. Nam, S. Nasonov, N. Nesterova, N. Nikolskaya, S. Nikolsky, V. Pavluchenko, Piskal, N. Romachina, V. Rubcov, A. Serdukov, A. Sizincev, A. Smirnov, P. Stavrev, K. Cherdyncewa, A. Chubenko, S. Shaulow, V. Yakovlev. Izvestiya AN USSR, ser. fiz., 50 N 11 (1986)

2. Analysis of the Electron and Muon Components of Extensive Air Showers at an Observation Level of 700 g cm^-2 with the Help of a Scale Breaking Interaction Model. J. Procureur, J. Stamenov, P. Stavrev, S. Ushev. J. Phys. G:Nucl. Phys. v11, N12, p1377-1386, (1985)

1. Zenith Angle Distribution Of The Cosmic Ray Muon Component. S.Kavlakov, P.Stavrev. Acta Physica Slovaca v. 34 (1984) No. 2-3

LIST OF CONFERENCE PRESENTATIONS AND WORKS PUBLISHED IN CONFERENCE PROCEEDINGS

41. Hristov, D., Stavrev, P., Sham, E., and Falone, B. G. (2002). “A method for the implementation of dose-volume objectives in gradient algorithms for inverse treatment planning.” Med Phys, 29(6), 1255-1255.

40. Stavrev, P., Hristov, D., Field, C., and Fallone, G. B. (2002). “Fractionation correction to Lyman's model.” Med Phys, 29(6), 1248-1248.

39. Stavrev, P., Warkentin, B., Stavreva, N., and Fallone, B. G. (2002). “Evaluation of a closed-form tumor control probability solution.” Med Phys, 29(6), 1248-1248.

38. Stavreva, N., and Stavrev, P. (2002). “Note on some limitations of the Kallman "Relative seriality" normal tissue complication probability model.” Med Phys, 29(6), 1248-1248.

37. Underwood, L., Murray, B., Robinson, D., Stavrev, P., Laassami, R., Halls, S., and Roa, W. (2002) “Dose-Escalation With Intensity-Modulated Radiotherapy For Cns Tumors Near The Optic Chiasm: Feasibility And Expected Outcome.” CARO, Toronto.

36. Amanie, J., Robinson, D., Murray, B., Field, C., Stavrev, P., Hennig, R., and Roa, W. (2002) “A Comparison Of Intensity Modulated And Three Dimensional Conformal Radiotherapy Plans In RTOG 93-11 Patients With Stage Iiib Non-Small Cell Lung Cancer.” CARO, Toronto.

35. Munroe, M., Parliament, M., Scrimger, R., Field, C., Stavrev, P., Thompson, H., and Santon, L. (2002) “Comparison of Inverse-Planned Intensity Modulated Radiotherapy (IMRT) And Helical Tomotherapy with Conventional Radiotherapy for a Nasopharyngeal Cancer Patient.” CARO, Toronto.

34. Scrimger, R., Stavrev, P., Parliament, M., Field, C., and Thompson, H. (2002) “Physical Parameters To Describe Normal Tissue Complication Probability (NTCP) For Parotid Gland Irradiation With Intensity-Modulated Radiotherapy (IMRT).” CARO, Toronto.

33. P. Stavrev, D Hristov, E Sham. IMRT Inverse Treatment Planing Optimization Based on Physical Constrains and Biological Objectives. Proc. of 47nd Annual General Meeting of the Canadian Organization of Medical Physicists (COMP), Kelowna, British Columbia, June 12-14, 2001.

32. D Hristov, E Sham, P. Stavrev, G Falone. Large-Scale Constrained Optimization for Inverse Treatment Planning. Proc. of 47nd Annual General Meeting of the Canadian Organization of Medical Physicists (COMP), Kelowna, British Columbia, June 12-14, 2001.

31. E Sham, D Hristov, P. Stavrev, G Falone. Inverse Treatment Planning by Simulated Annealing Minimization of a Dose-Volume Cost Function. Proc. of 47nd Annual General Meeting of the Canadian Organization of Medical Physicists (COMP), Kelowna, British Columbia, June 12-14, 2001.

30. A Bayesian Approach to the Problem of Calculating the Confidence Limits of the Probability of Success in Animal Experiments and Clinical Studies. Stavrev PV Stavrev NA 43 AAPM Annual Meeting, Salt Lake City, July 22-26, 2001

29. The Slope of the Dose-Response Curve for Tumors Versus Normal Organs. Stavrev PV, Niemierko A, Suit H, 43 AAPM Annual Meeting, Salt Lake City, July 22-26, 2001

28. Applying biological models to the treatment of hyper and conventional fractionated radiotherapy in animal experiments. Stavrev PV and Hristov DH, 43 AAPM Annual Meeting, Salt Lake City, July 22-26, 2001

27. Prostate IMRT fractionation strategies: two-phase treatment versus simultaneous integrated boost. Stavrev PV and Hristov DH, 43 AAPM Annual Meeting, Salt Lake City, July 22-26, 2001

26. Fits to Michigan liver data by the CV model. The problem of correlation between the model parameters. P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual Meeting, Nashville, 24-29 July, 1999. Med.Phys., 26, 6, p1122

25. General tissue response model. P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual Meeting, Nashville, 24-29 July, 1999. Med.Phys., 26, 6, p1130

24. Modeling the Dose-Volume Response of the Spinal Cord. N. Stavreva, A. Niemierko, P. Stavrev, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 10-14 August, 1998. Med.Phys., 25, 7, pA106

23. Fitting the Critical Volume NTCP Model to the Emami Data. P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 10-14 August, 1998. Med.Phys., 25, 7, pA208

22. 3D generalization of the iso-local TCP criterion applied to the LQ model of cell damage. P.V. Stavrev, N.A. Stavreva, W.H. Round. Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 27-28 November, 1997, Hamilton, NZ.

21. Dose Distribution Optimization Using a Multi-Target Model of Cell Damage. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 23-26 September, 1996, Vienna.

20. Dose Distribution Optimization Carried out for Multi-Target Model of Cell Damage Taking Treatment Fractionation into Account. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 23-26 September, 1996, Vienna.

19. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours when Linear-Quadratic Model of Cell Damage is Assumed. NA Stavreva, PV Stavrev, WH Round. 38th Annual Meeting of AAPM, Philadelphia, 21-26 July,1996

18. A Convolutional Method to Account for Tumour Mobility. P.V. Stavrev, N.A. Stavreva, W.H. Round. 38th Annual Meeting of AAPM, Philadelphia, 21-26 July,1996

17. A Study of Objective Functions for Organs with Parallel and Serial Architecture. PV Stavrev , NA Stavreva, WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown 20-24.11.1995

16. Dose Distribution Determination Taking the Tumour Mobility into Account. PV Stavrev , NA Stavreva, WH Round. 44th Annual Meeting of RRS, April 14-17, 1996, Chicago, Illinois

15. Dose and TCP Estimation Accounting for the Tumour Mobility. PV Stavrev , NA Stavreva, WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown 20-24.11.1995

14. A Differential and Variational Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours, Stavreva N. Stavrev P., Round WH. Annual Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 23-25 November,1994, Wellington

13. Mass composition of Cosmic Rays with E ~ 10¹⁵ - 10¹⁶ eV. New treatment of Tien-Shan and Akeno data. Stavrev P., Gavritova-Stavreva N., Petrov S. Proc. of 1st General Conference of the Balkan Phys.Union, 1991 sept. 26-28, Thessaloniki, Greece

12. Nonlinear optical susceptibility and vibronic spectra of helical polymers. I. J. Lalov, R. D. Atanasov, P. V. Stavrev. Proc. of 1st General Conference of the Balkan Phys. Union, 1991 sept. 26-28, Thessaloniki, Greece

11. Pharmacokinetic Approach for Individualization and Optimization of Drug Therapy. Michailova D, Stavrev P, Dishowski Ch. III Congress of the Bulgarian Pharmacological Society, 1991 may, Sofia

10. Numerical Optimization of Spherical Lenses with Quadratic Gradient Index. P. Stavrev, L. Atanasova. Proc. of IV National conference on "Optics and Laser Engineering", may 1989, Varna

9. A New Algorithm for Analysis of Data Obtained by Means of Circular Dichroism Titration Method (full text). N. Stavreva, V. Ruseva, D. Michailova, P. Stavrev. Proc of V IC Chemistry and Biotechnology of biologically active natural products, 1989, Varna, Bulgaria

8. A New Approach to MOS Structure Parameters Evaluation using High Frequency Capacity - Voltage Curves (full text). Kassabov J, Stavrev P, Dimitrov D., Proc. of ISPPME, Bulgaria, Varna, 1989

7. Investigation of the Nuclear Interactions on the Modern Tien-Shan Installation "HADRON". D. Adamov, V. Arabkin, K. Barkalov, R. Nam, A. Chubenko, A. Dubovy, V. Piskal, B. Kadyrsisov, N. Nikolskaya, N. Nesterova, S. Nikolsky, V. Pavluchenko, P. Stavrev, N. Vildanov, S. Shaulov. Proc. of 20ICRC, v5, HE3.5-5, p144, Moscow (1987) ( Full text)

6. Phenomenological Characteristics of EAS with N_e-=2.10⁵ - 2.10⁷Obtained by the Modern Tien-Shan Installation "HADRON". D. Adamov, B. Afanasjev, V. Arabkin, V. Aseikin, K. Barkalov, R. Nam,A. Gulyaev, P. Dyatlov, N. Romakhina, A. Chubenko, A. Dubovy, V. Piskal, B. Kadyrsisov, N. Nikolskaya, N. Nesterova, S. Nikolsky, S. Shaulov, V. Pavluchenko, P. Stavrev, N. Vildanov, L. Vildanova, A.Smirnov, Yu. Vasilyuk, V. Zhukov, V. Yakovlev. Proc. of 20ICRC, v5, HE3.1-21, p460, Moscow (1987) ( Full text)

5. EAS Front Fluctuations (text in full). K.Barkalov, A.Dubovy, N.Gavritova-Stavreva, P.Stavrev, S.Nikolsky, V.Pavluchenko, J.Stamenov. Proc.of 20ICRC, v6, HE3.3-5, p67, Moscow (1987)

4. Methods and conditions for optimal shower's direction estimation (full text). N. Gavritova-Stavreva, P. Stavrev, J. Stamenov, K. Barkalov. Proc. of 20ICRC, v6, HE7.1-3, p397, Moscow (1987)

3. Unstable Particles in the Cascades Initiated by Single Hadrons with Energies above 5 Tev in a Calorimeter with Lead Absorber (full text). A. Serdyukov, P. Stavrev, V. Yakovlev. Proc. of 20ICRC, v6, HE6.2-1, p356, Moscow (1987)

2. Analysis of the Hadron Component in EAS Observed at 700 g.cm^-2 by Scale Braking Model (full text). J Procureur, JN Stamenov, PV Stavrev, SZ Ushev. Proc. of 19ICRC, HE4.1-5,p9, La Jolla (1985)

1. Analysis of the Electron and Muon Components in EAS Observed at 700 g.cm^-2 using a Scale Braking Model and ‘Gamaisation’ Hypothesis (full text). J Procureur, JN Stamenov, PV Stavrev, SZ Ushev. Proc. of 19ICRC, HE5.4-8, p184, La Jolla (1985)