
Last updated: 01.10.2005. 
Pavel Vassilev Stavrev
Adress:
Telephone:
Email: pstavrev@phys.ualberta.ca Homepage:
http://med.phys.ualberta.ca/pstavrev/ Date of Birth: September 4, 1957 Place of Birth: Varna, Bulgaria Citizenships: Bulgaria, New Zealand
Education
History: · 93  97  D.Phil., Department of Physics, Waikato University, Hamilton, New Zealand · 81  82  M Sc., Faculty of Physics, Sofia University, Sofia, Bulgaria · 77  81  B.Sc., Faculty of Physics, Sofia University, Sofia, Bulgaria · 1975  Grammar School, Varna, Bulgaria
Employment History:
9/2001
– Currently Department of Medical
Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G
1Z2, Canada, Associate Medical Physicist · Deriving formulae for the slope of the doseresponse curve based on different radiobiological models · Investigating the Effect of Cell Repopulation on the Tumor Response to Fractionated External Radiotherapy · On some limitations of the application of the NTCP model describing the response of organs with ‘relatively serial’ structure · Fractionation correction to Lyman’s model · Evaluation of a closedform tumor control probability solution ·
A TCP  NTCP estimation module based on known models, parameter
sets and dosevolume histograms.
12/2000 – 9/2001 Medical Physics Unit, Montreal General Hospital & McGill University, Montreal, Research Associate ·
Prostate
IMRT fractionation strategies: twophase treatment versus simultaneous
integrated boost ·
IMRT inverse treatment planing optimization based on physical
constraints and biological objectives
12/1997 – 12/2000 Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Postdoctoral Research Fellow · Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics · Modeling the dosevolume response of the spinal cord, based on the idea of damage to contiguous functional subunits · Analysis of data using normal tissue complication probability models; finetuning of existing models and development of new ones · Binomial confidence limits to clinical data and animal experiments  a Bayesian approach
19911993 Stelana90 (Computer firm), Owner · Computer services and sales · Development of an information system for observation of the first contour liquid chemical composition in a water water nuclear reactor. Evaluating and controlling high temperature pH values. · Development of an expert system for individualization and optimization of drug therapy.
19901991 Institute of Nuclear Research and Nuclear Energy, Bulgarian Academy of Science, Sofia, Research Fellow · Mass composition of Cosmic Rays · Electromagnetic cascading of ultra  high energy photons
19871990 Institute of Solid State Physics, Bulgarian Academy of Science, Sofia, Research Fellow · Development of an algorithm and software estimating the parameters of SiSiO plates on the basis of CV curves measurement. · Monte Carlo simulations of the electron propagation in an inverse layer. ·
Creating a program for numerical optimization of spherical lenses
with quadratic gradient index. 19851987 Cosmic Ray Laboratory, Physical Institute P.N. Lebedev,
Soviet Academy of Science, Moscow, USSR (former), Research Fellow ·
I have
participated in the creation of the cosmic ray experiment "HADRON" on
the TienShan Cosmic Ray Station. My work was related to the development of a
new nanosecond accuracy device for time difference measurements
in extensive air shower registration. ·
Searching
for unstable particles (charmed
baryons) in the cascades initiated by
single hadrons
19821985
Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Science,
Sofia, Physicist · Working on
a cosmic ray experiment on peak Mussala, Bulgaria, measuring the secondary
cosmic ray particles. Servicing the muon telescope and participating in the
creation of the Neutron Supermonitor. · I worked also over the development of a program, solving twodimensional plus time parabolic partial differential equation (for the purposes of modeling Cosmic Rays modulation in the Heliosphere). Teaching Experience: 2002 – 4 lectures  Radiobiology course, CCI & University of Alberta 2001 – 4 lectures  Radiobiology course, CCI & University of Alberta 1997  6 lectures  first year Astronomy course, Waikato University, Hamilton, NZ 1995  Astrophysics Course (Solar Physics, Cosmic Rays and Compact Objects), Waikato University, Hamilton, NZ
Publications: 27 papers in refereed journals & 41 conference presentations
Research Interests: My research interests, as can be seen from the papers in which I am coauthor, are diverse and include Medical Physics, Astrophysics and Biophysics. Other topics of interest – Philosophy (Lao Tzu, Bhagavad Gita, Plato, Diogenis, Kant, Logical Positivists), History, Mathematics.
LIST OF PUBLICATIONS 29. Inverse
treatment planning by physically constrained minimization of a biological
objective function. Stavrev P, Hristov D, Warkentin
B, Sham E, Stavreva N and Fallone BG submitted
to Medical Physics
28.
Investigating the Effect of Cell Repopulation on the Tumor Response to
Fractionated External Radiotherapy N. A. Stavreva, P. V. Stavrev, B. Warkentin,
and B.G. Fallone submitted to Medical Physics
27. Breast
radiotherapy with inclusion of the internal mammary nodes: A comparison of
techniques with 3 dimensional planning. D. Severin, S. Connors, H. Thompson, S.
Rathee, P. Stavrev, J. Hanson, IJROBP, 2003 (in press)
26. Some
limitations of the application of the NTCP model describing the response of
organs with 'relatively serial' structure. N. A. Stavreva and P. V. Stavrev, Int
J Radiat Biol, vol. 78, pp. 94850; author reply 9512, 2002.
25.
Derivation of the expressions for gamma50 and D50 for different individual TCP
and NTCP models. N. Stavreva, P. Stavrev, B. Warkentin, and B. G. Fallone, Phys
Med Biol, vol. 47, pp. 3591604, 2002. 24. On the
implementation of dosevolume objectives in gradient algorithms for inverse
treatment planning. Hristov, D., Stavrev, P., Sham, E., and Fallone, B. G.
(2002). Med Phys, 29(5), 84856.
23. On the
consistent use of organ definitions and radiobiological models for the
evaluation of complication probabilities of "tubular" organs. Stavrev
PV, Hristov DH and. Seuntjens JP, IJROBP,2002
22. The
Application of Biological Models to Clinical Data. P. Stavrev, A. Niemierko, N.
Stavreva, M. Goitein. Physica Medica, 17, 2, p2, 2001
21. Modeling the
dosevolume response of the spinal cord, based on the idea of damage to
contiguous functional subunits. N. Stavreva, A. Niemierko, P. Stavrev, M Goitein. International Journal of Radiation Biology, 77, 5, 2001
20.
Generalization of a model of tissue response to radiation based on the idea of
functional subunits and binomial statistics. P Stavrev, N Stavreva, A
Niemierko and M Goitein. Phys. Med. Biol. 46, 5, p150118, 2001 19. Fraction size and dose parameters related to the incidence of pericardial effusions: Regarding Martel et al. Letter to the Editor. IJROBP 40(1): 55161; 1998. Stavrev P, Stavrev N. Int. J. of Rad. Onc. Biol. Phys. 48: (2) 611613 Sep 1 2000 18. A Study of Objective Functions for Organs with Parallel and Serial Architecture PV Stavrev, NA Stavreva, WH Round. Australasian Physical and Engineering Sciences in Medicine, 20, 1, 1997 17. A Mathematical Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours. Stavreva N. Stavrev P., Round WH. Acta Oncologica 35, 6, 1996, p727 16. A New Method for Optimum Dose Distribution Determination Taking Tumour Mobility into Account. PV Stavrev, NA Stavreva, WH Round. Physics in Medicine and Biology, 41, (1996), p16791689 15. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours. NA Stavreva, PV Stavrev, WH Round. Astralasian Physical and Engineering Sciences in Medicine, vol. 19, No 1, 1996, p9 14. Comment on 'A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density' by Webb and Nahum, Letter to the Editor. Stavreva N. Stavrev P., Round WH. Physics in Medicine and Biology, 40, (1995), p17311738 13. New Algorithm for Analysis of Data Obtained by Means of Circular Dichroism Titration Method. N.Stavreva, V.Ruseva, D.Michailova, P.Stavrev. Arzneimittel Forschung (Drug Research), 43(I), 73, 1993 12. Mass composition of Cosmic Rays with E ~ 10^{14}  10^{16}eV. New treatment of TienShan and Akeno data. Stavrev P., GavritovaStavreva N. , Petrov S. J. Phys. G:Nucl. Phys. (1992), p1832 11. Electromagnetic Cascading of Ultra  High Energy Photons ( E>5x10^{17} eV ) in the Earth's Magnetic Field. H. P. Vankov and P. V. Stavrev. Physics Letters B, v. 266, 1991 10. Nonlinear Theory of Relaxation of Unstable Magnetization Precession in ^{3}HeA. IA Fomin, DV Shopova, PV Stavrev. Journ. Exp. &Theor. Phys., v. 99, 1991, 1 9. Array for cascade’s form investigation with energies 10^{13}10^{15} eV using the cherenkov radiation in the atmosphere. S. Abdrashitov, Yu. Vasilyuk, N. GavritovaStavreva, V. Zhukov, S. Zujkov, A. Morozov, S. Nikolsky,A. Smirnov, P. Stavrev, V. Yakovlev. Preprint 189 P. N. Lebedev FIAN Moscow 1989 8. Analysis of the Dependence of the Time and Amplitude Characteristics of a Scintillation Detector on its Box Geometry (in Russian). P. Stavrev, N. Stavreva, Ch. Vankov, K. Barkalov, V. Yakovlev. Bulg. J. Phys. 16 (1989), 2,p 150 7. Analysis of Extensive Air Showers Zenith and Azimuth Distributions with E > 0.3 PeV Observed on the TienShan Cosmic Ray Array (in Russian). K.Barkalov, P.Stavrev, N.Nesterova, I.Kirov. Preprint 19 P. N. Lebedev, FIAN 1988 6. About CrossSection Increase of Hadron Interaction with Atmospheric Atomic Nuclei Based on the Altitude Dependence of EAS with E > 10 PeV (in Russian). K.Barkalov, A.Dubovy, P.Dyatlov, N.Nesterova, P.Stavrev. Kratkie soobstenia po fizike ,1987,12,p 25 5. Errors' Estimation of EAS Axis Angular Coordinates Determination ( in Russian ). J. Stamenov, P. Stavrev. Voprosy Atomnoi Nauki i Tehniki(VANT), (1987) 4. Cherenkov Detector for Atmospheric HighEnergy Cascades Investigation (in Russian). N. Aliev, T. Alimov, M. Kakharov, B. Machmudov, H. Nasrullaev, N. Sirodyev, N. Hakimov, Yu. Vasiluk, N. GavritovaStavreva, V. Zhukov, A. Morozov, S. Nikolsky, A. Smirnov, P. Stavrev, V. Yakovlev . Izvestiy AN SSSR, ser. fiz., t. 50 N 11 (1986) 3. "Hadron" Array for Investigation of Primary Cosmic Rays and Characteristics of Nuclear Interactions in the Atmosphere (in Russian). S. Abdrashitov, D. Adamov, V. Arabkin, V. Asejkin, B. Afanasiev, K. Barkalov, R. Bejsenbaev, Yu. Vasiluk, N. Vildanov, L. Vildanova, N. GavritovaStavreva, A. Guliaew, A. Dubovy, P. Diatlov V. Zhukov,B. Kadyrsizov, A. Kvashnin, A. Kolchin, A. Kruglov, A. Morozov, R. Nam, S. Nasonov, N. Nesterova, N. Nikolskaya, S. Nikolsky, V. Pavluchenko, Piskal, N. Romachina, V. Rubcov, A. Serdukov, A. Sizincev, A. Smirnov, P. Stavrev, K. Cherdyncewa, A. Chubenko, S. Shaulow, V. Yakovlev. Izvestiya AN USSR, ser. fiz., 50 N 11 (1986) 2. Analysis of the Electron and Muon Components of Extensive Air Showers at an Observation Level of 700 g cm^{2} with the Help of a Scale Breaking Interaction Model. J. Procureur, J. Stamenov, P. Stavrev, S. Ushev. J. Phys. G:Nucl. Phys. v11, N12, p13771386, (1985) 1. Zenith Angle Distribution Of The Cosmic Ray Muon Component. S.Kavlakov, P.Stavrev. Acta Physica Slovaca v. 34 (1984) No. 23
LIST OF CONFERENCE PRESENTATIONS AND WORKS PUBLISHED IN CONFERENCE PROCEEDINGS 41. Hristov, D., Stavrev, P., Sham, E., and Falone, B. G. (2002). “A method for the implementation of dosevolume objectives in gradient algorithms for inverse treatment planning.” Med Phys, 29(6), 12551255. 40. Stavrev, P., Hristov, D., Field, C., and Fallone, G. B. (2002). “Fractionation correction to Lyman's model.” Med Phys, 29(6), 12481248. 39. Stavrev, P., Warkentin, B., Stavreva, N., and Fallone, B. G. (2002). “Evaluation of a closedform tumor control probability solution.” Med Phys, 29(6), 12481248. 38. Stavreva, N., and Stavrev, P. (2002). “Note on some limitations of the Kallman "Relative seriality" normal tissue complication probability model.” Med Phys, 29(6), 12481248. 37. Underwood, L., Murray, B., Robinson, D., Stavrev, P., Laassami, R., Halls, S., and Roa, W. (2002) “DoseEscalation With IntensityModulated Radiotherapy For Cns Tumors Near The Optic Chiasm: Feasibility And Expected Outcome.” CARO, Toronto. 36. Amanie, J., Robinson, D., Murray, B., Field, C., Stavrev, P., Hennig, R., and Roa, W. (2002) “A Comparison Of Intensity Modulated And Three Dimensional Conformal Radiotherapy Plans In RTOG 9311 Patients With Stage Iiib NonSmall Cell Lung Cancer.” CARO, Toronto. 35. Munroe, M., Parliament, M., Scrimger, R., Field, C., Stavrev, P., Thompson, H., and Santon, L. (2002) “Comparison of InversePlanned Intensity Modulated Radiotherapy (IMRT) And Helical Tomotherapy with Conventional Radiotherapy for a Nasopharyngeal Cancer Patient.” CARO, Toronto. 34. Scrimger, R., Stavrev, P., Parliament, M., Field, C., and Thompson, H. (2002) “Physical Parameters To Describe Normal Tissue Complication Probability (NTCP) For Parotid Gland Irradiation With IntensityModulated Radiotherapy (IMRT).” CARO, Toronto. 33. P. Stavrev, D Hristov, E Sham. IMRT Inverse Treatment Planing Optimization Based on Physical Constrains and Biological Objectives. Proc. of 47nd Annual General Meeting of the Canadian Organization of Medical Physicists (COMP), Kelowna, British Columbia, June 1214, 2001. 32. D Hristov, E Sham, P. Stavrev, G Falone. LargeScale Constrained Optimization for Inverse Treatment Planning. Proc. of 47nd Annual General Meeting of the Canadian Organization of Medical Physicists (COMP), Kelowna, British Columbia, June 1214, 2001. 31.
E Sham, D Hristov, P. Stavrev, G Falone. Inverse Treatment Planning by Simulated
Annealing Minimization of a DoseVolume Cost Function. Proc. of 47nd Annual
General Meeting of the Canadian Organization of Medical Physicists (COMP),
Kelowna, British Columbia, June 1214, 2001. 30. A Bayesian
Approach to the Problem of Calculating the Confidence Limits of the Probability
of Success in Animal Experiments and Clinical Studies. Stavrev PV Stavrev NA 43
AAPM Annual Meeting, Salt Lake City, July 2226, 2001
29. The
Slope of the DoseResponse Curve for Tumors Versus Normal Organs. Stavrev PV,
Niemierko A, Suit H, 43 AAPM Annual Meeting, Salt Lake City, July 2226, 2001 28.
Applying biological models to the treatment of hyper and conventional fractionated
radiotherapy in animal experiments. Stavrev PV and Hristov DH, 43 AAPM
Annual Meeting, Salt Lake City, July 2226, 2001 27.
Prostate IMRT fractionation strategies: twophase treatment versus simultaneous
integrated boost. Stavrev PV and Hristov DH, 43 AAPM Annual Meeting, Salt Lake
City, July 2226, 2001 26. Fits to
Michigan liver data by the CV model. The problem of correlation between the
model parameters. P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual
Meeting, Nashville, 2429 July, 1999. Med.Phys., 26, 6, p1122
25. General tissue response model. P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual Meeting, Nashville, 2429 July, 1999. Med.Phys., 26, 6, p1130 24. Modeling the DoseVolume Response of the Spinal Cord. N. Stavreva, A. Niemierko, P. Stavrev, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 1014 August, 1998. Med.Phys., 25, 7, pA106 23. Fitting the Critical Volume NTCP Model to the Emami Data. P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 1014 August, 1998. Med.Phys., 25, 7, pA208 22. 3D generalization of the isolocal TCP criterion applied to the LQ model of cell damage. P.V. Stavrev, N.A. Stavreva, W.H. Round. Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 2728 November, 1997, Hamilton, NZ. 21. Dose Distribution Optimization Using a MultiTarget Model of Cell Damage. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 2326 September, 1996, Vienna. 20. Dose Distribution Optimization Carried out for MultiTarget Model of Cell Damage Taking Treatment Fractionation into Account. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 2326 September, 1996, Vienna. 19. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours when LinearQuadratic Model of Cell Damage is Assumed. NA Stavreva, PV Stavrev, WH Round. 38th Annual Meeting of AAPM, Philadelphia, 2126 July,1996 18. A Convolutional Method to Account for Tumour Mobility. P.V. Stavrev, N.A. Stavreva, W.H. Round. 38th Annual Meeting of AAPM, Philadelphia, 2126 July,1996 17. A Study of Objective Functions for Organs with Parallel and Serial Architecture. PV Stavrev , NA Stavreva, WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown 2024.11.1995 16. Dose Distribution Determination Taking the Tumour Mobility into Account. PV Stavrev , NA Stavreva, WH Round. 44th Annual Meeting of RRS, April 1417, 1996, Chicago, Illinois 15. Dose and TCP Estimation Accounting for the Tumour Mobility. PV Stavrev , NA Stavreva, WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown 2024.11.1995 14. A Differential and Variational Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours, Stavreva N. Stavrev P., Round WH. Annual Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 2325 November,1994, Wellington 13. Mass composition of Cosmic Rays with E ~ 10^{15}  10^{16} eV. New treatment of TienShan and Akeno data. Stavrev P., GavritovaStavreva N., Petrov S. Proc. of 1st General Conference of the Balkan Phys.Union, 1991 sept. 2628, Thessaloniki, Greece 12. Nonlinear optical susceptibility and vibronic spectra of helical polymers. I. J. Lalov, R. D. Atanasov, P. V. Stavrev. Proc. of 1st General Conference of the Balkan Phys. Union, 1991 sept. 2628, Thessaloniki, Greece 11. Pharmacokinetic Approach for Individualization and Optimization of Drug Therapy. Michailova D, Stavrev P, Dishowski Ch. III Congress of the Bulgarian Pharmacological Society, 1991 may, Sofia 10. Numerical Optimization of Spherical Lenses with Quadratic Gradient Index. P. Stavrev, L. Atanasova. Proc. of IV National conference on "Optics and Laser Engineering", may 1989, Varna 9. A New Algorithm for Analysis of Data Obtained by Means of Circular Dichroism Titration Method (full text). N. Stavreva, V. Ruseva, D. Michailova, P. Stavrev. Proc of V IC Chemistry and Biotechnology of biologically active natural products, 1989, Varna, Bulgaria 8. A New Approach to MOS Structure Parameters Evaluation using High Frequency Capacity  Voltage Curves (full text). Kassabov J, Stavrev P, Dimitrov D., Proc. of ISPPME, Bulgaria, Varna, 1989 7. Investigation of the Nuclear Interactions on the Modern TienShan Installation "HADRON". D. Adamov, V. Arabkin, K. Barkalov, R. Nam, A. Chubenko, A. Dubovy, V. Piskal, B. Kadyrsisov, N. Nikolskaya, N. Nesterova, S. Nikolsky, V. Pavluchenko, P. Stavrev, N. Vildanov, S. Shaulov. Proc. of 20ICRC, v5, HE3.55, p144, Moscow (1987) ( Full text) 6. Phenomenological Characteristics of EAS with N_{e}^{ }=2.10^{5}  2.10^{7 }Obtained by the Modern TienShan Installation "HADRON". D. Adamov, B. Afanasjev, V. Arabkin, V. Aseikin, K. Barkalov, R. Nam,A. Gulyaev, P. Dyatlov, N. Romakhina, A. Chubenko, A. Dubovy, V. Piskal, B. Kadyrsisov, N. Nikolskaya, N. Nesterova, S. Nikolsky, S. Shaulov, V. Pavluchenko, P. Stavrev, N. Vildanov, L. Vildanova, A.Smirnov, Yu. Vasilyuk, V. Zhukov, V. Yakovlev. Proc. of 20ICRC, v5, HE3.121, p460, Moscow (1987) ( Full text) 5. EAS Front Fluctuations (text in full). K.Barkalov, A.Dubovy, N.GavritovaStavreva, P.Stavrev, S.Nikolsky, V.Pavluchenko, J.Stamenov. Proc.of 20ICRC, v6, HE3.35, p67, Moscow (1987) 4. Methods and conditions for optimal shower's direction estimation (full text). N. GavritovaStavreva, P. Stavrev, J. Stamenov, K. Barkalov. Proc. of 20ICRC, v6, HE7.13, p397, Moscow (1987) 3. Unstable Particles in the Cascades Initiated by Single Hadrons with Energies above 5 Tev in a Calorimeter with Lead Absorber (full text). A. Serdyukov, P. Stavrev, V. Yakovlev. Proc. of 20ICRC, v6, HE6.21, p356, Moscow (1987) 2. Analysis of the Hadron Component in EAS Observed at 700 g.cm^{2} by Scale Braking Model (full text). J Procureur, JN Stamenov, PV Stavrev, SZ Ushev. Proc. of 19ICRC, HE4.15,p9, La Jolla (1985) 1. Analysis of the Electron and Muon Components in EAS Observed at 700 g.cm^{2} using a Scale Braking Model and ‘Gamaisation’ Hypothesis (full text). J Procureur, JN Stamenov, PV Stavrev, SZ Ushev. Proc. of 19ICRC, HE5.48, p184, La Jolla (1985) 
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