
Last updated: 01.10.2005. 
CURRICULUM VITAE
Nadejda A.
GavritovaStavreva
Address: 11135 – 83 Ave, apt # 2109 Edmonton Alberta T6G 2C6 Canada Telephone: (780) 9893368 (home) (780) 989 4334 (work) email: nstavrev@phys.ualberta.ca Date of Birth: May 6, 1957 Place of Birth: Sofia, Bulgaria Citizenship: Bulgaria, New Zealand Education
History: · 1993  1997 D.Phil., Radiobiological Models in Radiation Therapy, Department of Physics, Waikato University, Hamilton, New Zealand. ·
1989 1992
Postgraduate Qualification in Medical Physics, Department of Physics and
Biophysics, Medical Academy, Sofia, Bulgaria ·
1980  1981
MSc in Cosmic
Ray Physics,
Faculty of Physics, Sofia University, Sofia, Bulgaria ·
1976  1980
BSc in Atomic Physics, Faculty
of Physics, Sofia University, Sofia,
Bulgaria ·
1971  1976
English Language School, Sofia, Bulgaria Employment
History 2001  Research Fellow, Department of Medical Physics, Cross Cancer Institute, Edmonton, AB ·
Derivation of the
expressions for the position and slope of the responses of individual tumors
(Tumor Control Probability – TCP) and normal tissues (Normal Tissue
Complication Probability – NTCP) to radiation ·
Investigation of the impact
of interindividual variability of different model parameters on the response
(TCP and NTCP) of a population to radiation ·
Investigation of the
effects of cellular sublethal damage repair, repopulation and resensitization
that may occur in a dynamic cell population (tumor or normal tissue) for a
protracted in time treatment – fractionated external treatment, brachytherapy,
radioactive nuclide applications 1997  2000 Research
Fellow, Department of Radiation Oncology, Massachusetts General Hospital &
Harvard Medical School, Boston, MA · Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics · Modeling the dosevolume response of the spinal cord, based on the idea of damage to contiguous functional subunits · Analysis of data using normal tissue complication probability models; finetuning of existing models and development of new ones · Applying a Bayesian approach to the problem of determining the binomial confidence limits in clinical data and animal experiments · Deriving a new formula for the probability of consecutive koutofn trials – binomial distribution of order k. 1988
 1993 Assistant Professor,
Department of
Physics and Biophysics, Medical Academy, Faculty of Medicine, Sofia ·
Data treatment and modeling
of biophysical processes using physical methods in biophysics
·
Investigation of
Fe^{2+}  induced lipid
peroxidation through
chemoluminescence and TBA test methods ·
Investigation of anti and
prooxidant activity of drugs ·
Investigation of drugblood
protein binding analyzing circular dichroism data 19871988
Programmer, Computer Center, Bulgarian Academy of Science, Sofia, 19851987 Research Fellow, Cosmic Ray Laboratory, Physical Institute P.Lebedev and the TienShan Cosmic Ray Station, Soviet Academy of Science, Moscow, USSR (former) ·
Participation in the creation of the cosmic ray
experiment "HADRON" on the TienShan Cosmic Ray Station ·
Analysis of the front fluctuations
in the Extensive Air Showers (secondary cosmic rays) ·
Analysis of the mass composition of the primary
cosmic rays Teaching
Experience: ·
Teaching Medical Physics
and Biophysics to medical students in the Dept of Physics and Biophysics,
Medical Academy, Sofia ·
Lectures in Biophysics as
part of the course in Medical Physics taught
on the masters level at the Waikato University, Hamilton:
i.
Thermodynamics of biochemical systems
ii.
Cellular and organelle membranes
iii.
Transport processes
iv.
Active potentials
v.
Basic radiophysics and radiobilogy
vi.
Nonlinear processes Research Interests: Biophysics,
Biochemistry, Medical Physics, Thermodynamics and Nonlinear dynamics,
Astrophysics
LIST OF PUBLICATIONS 21.
Inverse treatment planning by physically constrained minimization of a
biological objective function. Stavrev P, Hristov D, Warkentin
B, Sham E, Stavreva N and Fallone BG, Medical Physics,
submitted. 20. Investigating the Effect of Cell
Repopulation on the Tumor Response to Fractionated External Radiotherapy. N. A.
Stavreva, P. V. Stavrev, B. Warkentin, and B.G. Fallone, Medical Physics, in
press. 19.
Note on some limitations of the application of the NTCP model describing the
response of organs with ‘relatively serial’ structure. Stavreva NA, Stavrev
PV, Int. J Rad. Biol., vol.
78, 2002, p 94850
18. Derivation of the expressions for g_{50} and D_{50} for different individual TCP and NTCP model functions. Stavreva NA, Stavrev PV, Warkentin B, Fallone BG, Phys. Med. Biol. 47, 2002, p 3591604 17. The Application of Biological Models to Clinical Data.
P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. Physica Medica, Vol. XVII,
N2, 2001
16. Modeling the dosevolume response of the spinal cord,
based on the idea of damage to contiguous functional subunits. N. Stavreva, A.
Niemierko, P. Stavrev, M Goitein. International Journal of Radiation Biology,
77, 5, 2001
15.
Generalization of a model of tissue response to radiation based on the idea of
functional subunits and binomial statistics. P
Stavrev, N Stavreva, A Niemierko and M Goitein. Phys. Med. Biol. 46, 5,
p150118, 2001 14. Fraction size and dose parameters related to the incidence of pericardial effusions: Regarding Martel et al. Letter to the Editor. IJROBP 40(1): 55161; 1998. Stavrev P, Stavrev N. Int. J. of Rad. Onc. Biol. Phys. 48: (2) 611613 Sep 1 2000 13. A Study of Objective Functions for Organs with Parallel and Serial Architecture. PV Stavrev, NA Stavreva, WH Round. Australasian Physical and Engineering Sciences in Medicine, 20, 1, 1997 12. A Mathematical Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours. Stavreva N. Stavrev P., Round WH. Acta Oncologica 35, 6, 1996, p727 11. A New Method for Optimum Dose Distribution Determination Taking Tumour Mobility into Account. PV Stavrev, NA Stavreva, WH Round. Physics in Medicine and Biology, 41, (1996), p16791689 10. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours. NA Stavreva, PV Stavrev, WH Round. Astralasian Physical and Engineering Sciences in Medicine, vol. 19, No 1, 1996, p9 9. Comment on 'A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density' by Webb and Nahum, Letter to the Editor. Stavreva N. Stavrev P., Round WH. Physics in Medicine and Biology, 40, (1995), p17311738 8.
Binding of Sulindac to Human Serum Albumin Studied by Circular Dichroism.
Russeva V., Stavreva N., Rakovska R., Michailova D. Arzneimittel Forschung (Drug
Research) 44(I), 2, 1994 7. Binding of Ketoprofen to Human SerumAlbumin Studied by Circular Dichroism. Russeva V., Rakovska R., Stavreva N., Michailova D. Pharmazia, 1994, Vol 49, Iss 7, pp 519522 6. New Algorithm for Analysis of Data Obtained by Means of Circular Dichroism Titration Method. N.Stavreva, V.Ruseva, D.Michailova, P.Stavrev. Arzneimittel Forschung (Drug Research), 43(I), 73, 1993 5. Mass composition of Cosmic Rays with E > 10^{14}  10^{16}eV. New treatment of TienShan and Akeno data. Stavrev P., GavritovaStavreva N. , Petrov S. J. Phys. G:Nucl. Phys. (1992), p1832 4. Array for cascade’s form investigation with energies 10^{13}10^{15} eV using the Cherenkov radiation in the atmosphere. S. Abdrashitov, Yu. Vasilyuk, N. GavritovaStavreva, V. Zhukov, S. Zujkov, A. Morozov, S. Nikolsky,A. Smirnov, P. Stavrev, V. Yakovlev. Preprint 189 P. N. Lebedev FIAN Moscow 1989 3. Analysis of the Dependence of the Time and Amplitude Characteristics of a Scintillation Detector on its Box Geometry (in Russian). P. Stavrev, N. Stavreva, Ch. Vankov, K. Barkalov, V. Yakovlev. Bulg. J. Phys. 16 (1989), 2,p 150 2. Cherenkov Detector for Atmospheric HighEnergy Cascades Investigation (in Russian). N. Aliev, T. Alimov, M. Kakharov, B. Machmudov, H. Nasrullaev, N. Sirodyev, N. Hakimov, Yu. Vasiluk, N. GavritovaStavreva, V. Zhukov, A. Morozov, S. Nikolsky, A. Smirnov, P. Stavrev, V. Yakovlev . Izvestiy AN SSSR, ser. fiz., t. 50 N 11 (1986) 1. "Hadron" Array for Investigation of Primary Cosmic Rays and Characteristics of Nuclear Interactions in the Atmosphere (in Russian). S. Abdrashitov, D. Adamov, V. Arabkin, V. Asejkin, B. Afanasiev, K. Barkalov, R. Bejsenbaev, Yu. Vasiluk, N. Vildanov, L. Vildanova, N. GavritovaStavreva, A. Guliaew, A. Dubovy, P. Diatlov V. Zhukov,B. Kadyrsizov, A. Kvashnin, A. Kolchin, A. Kruglov, A. Morozov, R. Nam, S. Nasonov, N. Nesterova, N. Nikolskaya, S. Nikolsky, V. Pavluchenko, Piskal, N. Romachina, V. Rubcov, A. Serdukov, A. Sizincev, A. Smirnov, P. Stavrev, K. Cherdyncewa, A. Chubenko, S. Shaulow, V. Yakovlev. Izvestiya AN USSR, ser. fiz., 50 N 11 (1986)
LIST OF CONFERENCE PRESENTATIONS AND WORKS PUBLISHED IN CONFERENCE PROCEEDINGS 23. Stavrev, P., Warkentin, B., Stavreva, N., and Fallone, B. G. “Evaluation of a closedform tumor control probability solution.” 44 AAPM Annual Meeting, Montreal, July 2002, Med Phys, 29(6), 12481248. 22. Stavreva, N., and Stavrev, P. “Note on some limitations of the Kallman "Relative seriality" normal tissue complication probability model.” 44 AAPM Annual Meeting, Montreal, July 2002, Med Phys, 29(6), 12481248. 21. A Bayesian Approach to the Problem of Calculating the
Confidence Limits of the Probability of Success in Animal Experiments and
Clinical Studies. Stavrev PV Stavrev NA 43 AAPM Annual Meeting, Salt Lake City,
July 2226, 2001
20. Fits to Michigan liver data by the CV model. The problem
of correlation between the model parameters. P.Stavrev A.Niemierko N.Stavreva
M.Goitein. 41th AAPM Annual Meeting, Nashville, 2429 July, 1999. Med.Phys., 26,
6, p1122
19. General tissue response model. P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual Meeting, Nashville, 2429 July, 1999. Med.Phys., 26, 6, p1130 18. Modeling the DoseVolume Response of the Spinal Cord. N. Stavreva, A. Niemierko, P. Stavrev, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 1014 August, 1998. Med.Phys., 25, 7, pA106 17. Fitting the Critical Volume NTCP Model to the Emami Data. P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 1014 August, 1998. Med.Phys., 25, 7, pA208 16. 3D generalization of the isolocal TCP criterion applied to the LQ model of cell damage. P.V. Stavrev, N.A. Stavreva, W.H. Round. Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 2728 November, 1997, Hamilton, NZ. 15. Dose Distribution Optimization Using a MultiTarget Model of Cell Damage. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 2326 September, 1996, Vienna. 14. Dose Distribution Optimization Carried out for MultiTarget Model of Cell Damage Taking Treatment Fractionation into Account. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 2326 September, 1996, Vienna. 13. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours when LinearQuadratic Model of Cell Damage is Assumed. NA Stavreva, PV Stavrev, WH Round. 38th Annual Meeting of AAPM, Philadelphia, 2126 July, 1996 12. A Convolutional Method to Account for Tumour Mobility. P.V. Stavrev, N.A. Stavreva, W.H. Round. 38th Annual Meeting of AAPM, Philadelphia, 2126 July,1996 11. Dose Distribution Determination Taking the Tumour Mobility into Account. PV Stavrev , NA Stavreva, WH Round. 44th Annual Meeting of RRS, April 1417, 1996, Chicago, Illinois 10. A Study of Objective Functions for Organs with Parallel and Serial Architecture. PV Stavrev, NA Stavreva, WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown, NZ, 2024.11.1995 9.
Dose and TCP Estimation Accounting for the Tumour Mobility. PV Stavrev , NA Stavreva,
WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown,
NZ, 2024.11.1995 8. A Differential and Variational Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours, Stavreva N. Stavrev P., Round WH. Annual Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 2325 November,1994, Wellington, NZ 7. Estimation of
Antioxidant and Immunomodulation Activities of Some Nueroleptics. Goliiski P.,
Traykov T., Stavreva N., Ribarov S. X Balkan Biochemical and Biophysical Days,
2225 May, 1994, Varna, Bulgaria 6. Estimation of
Antioxidant and Immunomodulation Activities of Some Antidepressants. Traykov T.,
Goliiski P., Stavreva N., Ribarov
S. X Balkan Biochemical and Biophysical Days, 2225 May, 1994, Varna, Bulgaria 5.
Investigation of Anti or Prooxidant Activity of Drugs and Bioactive Substunces.
Stavreva N., Goliiski P., Galabova T. VI National Conference on Biomedical
Physics and Technics, 1992, 2224 Oct., Sofia, Bulgaria 4.
Mass composition of Cosmic Rays with E ~ 10^{15}  10^{16} eV. New treatment
of TienShan
and Akeno
data. Stavrev
P., GavritovaStavreva N., Petrov S. Proc. of 1st General Conference of
the Balkan Phys.Union, 1991 sept. 2628,
Thessaloniki, Greece 3.
A New Algorithm for Analysis of Data Obtained by
Means of Circular Dichroism
Titration Method (full text). N.
Stavreva, V. Ruseva, D. Michailova, P. Stavrev. Proc of V IC Chemistry and
Biotechnology of biologically active natural products, 1989, Varna, Bulgaria 2. Extensive Air Showers Front Fluctuations (text in full). K.Barkalov, A.Dubovy, N.GavritovaStavreva, P.Stavrev, S.Nikolsky, V.Pavluchenko, J.Stamenov. Proc.of 20 ICRC, v6, HE3.35, p67, Moscow (1987) 1. Methods and conditions for optimal shower's direction estimation (text in full). N. GavritovaStavreva, P. Stavrev, J. Stamenov, K. Barkalov. Proc. of 20ICRC, v6, HE7.13, p397, Moscow (1987) 
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