Last updated: 01.10.2005.

CURRICULUM VITAE

Nadejda A. Gavritova-Stavreva

Address:  

            11135 – 83 Ave, apt # 2109

Edmonton

Alberta T6G 2C6

Canada

Telephone: (780) 989-3368  (home)

                 (780) 989 4334 (work)         

                                            e-mail:       nstavrev@phys.ualberta.ca

Date of Birth:                May 6, 1957

Place of Birth:               Sofia, Bulgaria

Citizenship:                   Bulgaria, New Zealand

Education History:   

·        1993 - 1997  D.Phil., Radiobiological Models in Radiation Therapy, Department of Physics, Waikato University, Hamilton, New Zealand.

·        1989 -1992  Postgraduate Qualification in Medical Physics, Department of Physics and Biophysics, Medical Academy, Sofia, Bulgaria

·        1980 - 1981  MSc    in Cosmic Ray  Physics,  Faculty of Physics, Sofia University, Sofia, Bulgaria

·        1976 - 1980  BSc in Atomic Physics,  Faculty of Physics, Sofia University,  Sofia, Bulgaria

·        1971 - 1976  English Language School, Sofia, Bulgaria

Employment History

2001  -   Research Fellow, Department of Medical Physics, Cross Cancer Institute, Edmonton, AB

·        Derivation of the expressions for the position and slope of the responses of individual tumors (Tumor Control Probability – TCP) and normal tissues (Normal Tissue Complication Probability – NTCP) to radiation

·        Investigation of the impact of interindividual variability of different model parameters on the response (TCP and NTCP) of a population to radiation

·        Investigation of the effects of cellular sublethal damage repair, repopulation and resensitization that may occur in a dynamic cell population (tumor or normal tissue) for a protracted in time treatment – fractionated external treatment, brachytherapy, radioactive nuclide applications

1997 - 2000  Research Fellow, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA

·        Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics

·        Modeling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits

·        Analysis of data using normal tissue complication  probability models; fine-tuning of existing models and development of new ones

·        Applying a Bayesian approach to the problem of determining the binomial confidence limits in clinical data and animal experiments

·        Deriving a new formula for the probability of consecutive k-out-of-n trials – binomial distribution of order k.

1988 - 1993  Assistant Professor,  Department  of  Physics and Biophysics, Medical Academy, Faculty of Medicine, Sofia

·        Data treatment and modeling of biophysical processes using physical methods in biophysics  

·        Investigation of  Fe²⁺ - induced  lipid  peroxidation  through chemoluminescence and TBA test methods

·        Investigation of anti- and pro-oxidant activity of drugs

·        Investigation of drug-blood protein binding analyzing circular dichroism data

1987-1988  Programmer, Computer Center, Bulgarian Academy of Science, Sofia,

1985-1987 Research Fellow, Cosmic Ray Laboratory, Physical Institute P.Lebedev and the Tien-Shan Cosmic Ray Station, Soviet Academy of Science,  Moscow,  USSR (former)

·        Participation in the creation of the cosmic ray experiment "HADRON" on the Tien-Shan Cosmic Ray Station

·        Analysis of the front fluctuations in the Extensive Air Showers (secondary cosmic rays)

·        Analysis of the mass composition of the primary cosmic rays

Teaching Experience:

·        Teaching Medical Physics and Biophysics to medical students in the Dept of Physics and Biophysics, Medical Academy, Sofia

·        Lectures in Biophysics as part of the course in Medical Physics taught  on the masters level at the Waikato University, Hamilton:

         i.       Thermodynamics of biochemical systems

       ii.       Cellular and organelle membranes

      iii.       Transport processes

     iv.       Active potentials

       v.       Basic radiophysics and radiobilogy

     vi.       Non-linear processes

Research Interests:

Biophysics, Biochemistry, Medical Physics, Thermodynamics and Non-linear dynamics, Astrophysics

LIST OF PUBLICATIONS

21. Inverse treatment planning by physically constrained minimization of a biological objective function. Stavrev P, Hristov D, Warkentin B, Sham E, Stavreva N and Fallone BG, Medical Physics, submitted.

20. Investigating the Effect of Cell Repopulation on the Tumor Response to Fractionated External Radiotherapy. N. A. Stavreva, P. V. Stavrev, B. Warkentin, and B.G. Fallone, Medical Physics, in press.

19. Note on some limitations of the application of the NTCP model describing the response of organs with ‘relatively serial’ structure. Stavreva NA, Stavrev PV, Int. J Rad. Biol., vol. 78, 2002, p 948-50

18. Derivation of the expressions for g₅₀ and D₅₀ for different individual TCP and NTCP model functions. Stavreva NA, Stavrev PV, Warkentin B, Fallone BG, Phys. Med. Biol. 47, 2002, p 3591-604

17. The Application of Biological Models to Clinical Data. P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. Physica Medica, Vol. XVII, N2, 2001

16. Modeling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits. N. Stavreva, A. Niemierko, P. Stavrev, M Goitein. International Journal of Radiation Biology, 77, 5, 2001

15. Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics. P Stavrev, N Stavreva, A Niemierko and M Goitein. Phys. Med. Biol. 46, 5, p1501-18, 2001

14. Fraction size and dose parameters related to the incidence of pericardial effusions: Regarding Martel et al. Letter to the Editor.  IJROBP 40(1): 55-161; 1998.  Stavrev P, Stavrev N. Int. J. of Rad. Onc. Biol. Phys. 48: (2) 611-613 Sep 1 2000

13. A Study of Objective Functions for Organs with Parallel and Serial Architecture. PV Stavrev, NA Stavreva, WH Round. Australasian Physical and Engineering Sciences in Medicine, 20, 1, 1997

12. A Mathematical Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours. Stavreva N. Stavrev P., Round WH. Acta Oncologica 35, 6, 1996, p727

11. A New Method for Optimum Dose Distribution Determination Taking  Tumour Mobility into Account. PV Stavrev, NA Stavreva, WH Round. Physics in Medicine and Biology, 41, (1996), p1679-1689

10. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours. NA Stavreva, PV Stavrev, WH Round. Astralasian Physical and Engineering Sciences in Medicine, vol. 19, No 1, 1996, p9

9. Comment on 'A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density' by Webb and Nahum, Letter to the Editor. Stavreva N. Stavrev P., Round WH. Physics in Medicine and Biology, 40, (1995), p1731-1738

8. Binding of Sulindac to Human Serum Albumin Studied by Circular Dichroism. Russeva V., Stavreva N., Rakovska R., Michailova D. Arzneimittel Forschung (Drug Research) 44(I), 2, 1994

7. Binding of Ketoprofen to Human Serum-Albumin Studied by Circular Dichroism. Russeva V., Rakovska R., Stavreva N., Michailova D. Pharmazia, 1994, Vol 49, Iss 7, pp 519-522

6. New Algorithm for Analysis of Data Obtained by Means of Circular Dichroism Titration Method. N.Stavreva, V.Ruseva, D.Michailova, P.Stavrev. Arzneimittel Forschung  (Drug Research), 43(I), 73, 1993

5. Mass composition of Cosmic Rays with E > 10¹⁴ - 10¹⁶eV.  New treatment  of Tien-Shan and  Akeno  data. Stavrev P., Gavritova-Stavreva N. , Petrov S. J. Phys. G:Nucl. Phys.  (1992), p1832

4. Array  for cascade’s  form investigation with energies  10¹³-10¹⁵ eV using the  Cherenkov  radiation  in the  atmosphere. S. Abdrashitov, Yu. Vasilyuk, N. Gavritova-Stavreva, V. Zhukov,  S. Zujkov, A. Morozov, S. Nikolsky,A. Smirnov, P. Stavrev,  V. Yakovlev. Preprint  189  P. N. Lebedev FIAN Moscow 1989

3. Analysis of the Dependence of the Time and Amplitude Characteristics of a Scintillation Detector on its Box Geometry (in Russian). P. Stavrev, N. Stavreva, Ch. Vankov, K. Barkalov, V. Yakovlev. Bulg. J. Phys.  16 (1989), 2,p 150

2. Cherenkov Detector for Atmospheric  High-Energy  Cascades Investigation  (in Russian). N.  Aliev, T. Alimov, M. Kakharov, B. Machmudov, H. Nasrullaev, N. Sirodyev, N. Hakimov, Yu. Vasiluk, N. Gavritova-Stavreva, V. Zhukov, A. Morozov, S. Nikolsky, A. Smirnov, P. Stavrev, V. Yakovlev . Izvestiy AN SSSR, ser. fiz., t. 50 N 11 (1986)

1. "Hadron" Array for Investigation of Primary Cosmic Rays and Characteristics of Nuclear Interactions in the Atmosphere  (in Russian). S. Abdrashitov, D. Adamov, V. Arabkin, V. Asejkin, B. Afanasiev, K. Barkalov, R. Bejsenbaev, Yu. Vasiluk, N. Vildanov, L. Vildanova, N. Gavritova-Stavreva, A. Guliaew, A. Dubovy, P. Diatlov   V. Zhukov,B. Kadyrsizov, A. Kvashnin, A. Kolchin, A. Kruglov, A. Morozov, R. Nam, S. Nasonov, N. Nesterova, N. Nikolskaya, S. Nikolsky, V. Pavluchenko, Piskal, N. Romachina, V. Rubcov, A. Serdukov, A. Sizincev, A. Smirnov, P. Stavrev, K. Cherdyncewa, A.  Chubenko, S.  Shaulow, V.  Yakovlev. Izvestiya  AN USSR, ser. fiz., 50  N 11 (1986)

LIST OF CONFERENCE PRESENTATIONS AND WORKS PUBLISHED IN CONFERENCE PROCEEDINGS

23. Stavrev, P., Warkentin, B., Stavreva, N., and Fallone, B. G. “Evaluation of a closed-form tumor control probability solution.” 44 AAPM Annual Meeting, Montreal, July 2002, Med Phys, 29(6), 1248-1248.

22. Stavreva, N., and Stavrev, P. “Note on some limitations of the Kallman "Relative seriality" normal tissue complication probability model.” 44 AAPM Annual Meeting, Montreal, July 2002, Med Phys, 29(6), 1248-1248.

21. A Bayesian Approach to the Problem of Calculating the Confidence Limits of the Probability of Success in Animal Experiments and Clinical Studies. Stavrev PV Stavrev NA 43 AAPM Annual Meeting, Salt Lake City, July 22-26, 2001

20. Fits to Michigan liver data by the CV model. The problem of correlation between the model parameters. P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual Meeting, Nashville, 24-29 July, 1999. Med.Phys., 26, 6, p1122

19. General  tissue response  model.  P.Stavrev A.Niemierko N.Stavreva M.Goitein. 41th AAPM Annual Meeting, Nashville, 24-29 July, 1999. Med.Phys., 26, 6, p1130

18. Modeling the Dose-Volume Response of the Spinal Cord. N. Stavreva, A. Niemierko, P. Stavrev, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 10-14 August, 1998. Med.Phys., 25, 7, pA106

17. Fitting the Critical  Volume NTCP Model to the Emami Data. P. Stavrev, A. Niemierko, N. Stavreva, M. Goitein. 40th AAPM Annual Meeting, San Antonio, 10-14 August, 1998. Med.Phys., 25, 7, pA208

16. 3D generalization of the iso-local TCP criterion applied to the LQ model of cell damage. P.V. Stavrev, N.A. Stavreva, W.H. Round. Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 27-28 November, 1997, Hamilton, NZ.

15. Dose Distribution Optimization Using a Multi-Target Model of Cell Damage. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 23-26 September, 1996, Vienna.

14. Dose Distribution Optimization  Carried  out for Multi-Target  Model of Cell Damage Taking Treatment  Fractionation  into Account. NA Stavreva, PV Stavrev, WH Round. 15th Annual Meeting of ESTRO, 23-26 September, 1996, Vienna.

13. A Variational Approach to the Problem of Optimizing the Radiation Dose Distribution in Tumours when Linear-Quadratic Model of Cell Damage is Assumed. NA Stavreva, PV Stavrev, WH Round. 38th Annual Meeting of AAPM, Philadelphia, 21-26 July, 1996

12. A Convolutional Method to Account for Tumour Mobility. P.V. Stavrev, N.A. Stavreva,  W.H. Round. 38th Annual Meeting of AAPM, Philadelphia, 21-26 July,1996

11. Dose Distribution Determination Taking  the Tumour Mobility  into Account. PV Stavrev , NA Stavreva,  WH Round. 44th Annual Meeting of RRS, April 14-17, 1996, Chicago, Illinois

10. A Study of Objective Functions for Organs with Parallel  and Serial Architecture. PV Stavrev, NA Stavreva, WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown, NZ, 20-24.11.1995

9. Dose and TCP Estimation Accounting  for the Tumour Mobility. PV Stavrev , NA Stavreva,  WH Round. Engineering and Physics in Medicine 95 Conference, Qweenstown, NZ, 20-24.11.1995

8. A Differential and Variational Approach to Optimizing the Radiation Dose Distribution in Heterogeneous Tumours, Stavreva N. Stavrev P., Round WH. Annual Conference of the NZ Branch of the Austalasian College of Physical Scientists and Engineers in Medicine, 23-25 November,1994, Wellington, NZ

7. Estimation of Antioxidant and Immunomodulation Activities of Some Nueroleptics. Goliiski P., Traykov T., Stavreva N., Ribarov S. X Balkan Biochemical and Biophysical Days, 22-25 May, 1994, Varna, Bulgaria

6. Estimation of Antioxidant and Immunomodulation Activities of Some Antidepressants. Traykov T., Goliiski P.,  Stavreva N., Ribarov S. X Balkan Biochemical and Biophysical Days, 22-25 May, 1994, Varna, Bulgaria

5. Investigation of Anti- or Prooxidant Activity of Drugs and Bioactive Substunces. Stavreva N., Goliiski P., Galabova T. VI National Conference on Biomedical Physics and Technics, 1992, 22-24 Oct., Sofia, Bulgaria

4. Mass composition of Cosmic Rays with E ~ 10¹⁵ - 10¹⁶   eV. New  treatment  of  Tien-Shan  and  Akeno  data.  Stavrev  P., Gavritova-Stavreva N., Petrov S. Proc. of 1st General Conference of the Balkan Phys.Union, 1991 sept.  26-28, Thessaloniki,  Greece

3. A New Algorithm for Analysis of Data Obtained by  Means  of Circular Dichroism Titration Method  (full text). N. Stavreva, V. Ruseva, D. Michailova, P. Stavrev. Proc of V IC Chemistry and Biotechnology of biologically active natural products, 1989, Varna, Bulgaria

2. Extensive Air Showers Front Fluctuations (text in full). K.Barkalov, A.Dubovy, N.Gavritova-Stavreva, P.Stavrev, S.Nikolsky, V.Pavluchenko, J.Stamenov. Proc.of 20 ICRC, v6, HE3.3-5, p67, Moscow (1987)

1. Methods and conditions for optimal shower's  direction estimation (text in full). N. Gavritova-Stavreva, P. Stavrev,  J. Stamenov, K. Barkalov. Proc. of 20ICRC, v6, HE7.1-3, p397, Moscow (1987)

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